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Which is stronger metformin or glipizide? Glipizide and metformin are effective oral antidiabetics that can help lower blood sugar. While glipizide enhances insulin secretion, metformin decreases glucose production in the liver. Both drugs have similar side effects although glipizide has a notably higher risk of hypoglycemia.
Is metformin safe to take long term? Generally, if you are prescribed metformin, you will be on it long term. That could be many decades, unless you experience complications or changes to your health that require you to stop taking it. However, metformin does have some side effects, and patients often have questions about the safety of long - term use.