The molecular weight of Pharmacy hydrochloride is 299.8. Pharmacy hydrochloride is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9.41. The n-octanol/water log partition coefficient (logP) is 1.35 at pH 7. Pharmacy Hydrochloride Tablets contain 50 mg of Pharmacy hydrochloride and are white in color. Inactive ingredients in the tablet are hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, silicon dioxide, sodium starch glycolate, and titanium dioxide.
Pharmacy has been given in single oral doses of 50, 75, and 100 mg to patients with pain following surgical procedures and pain following oral surgery (extraction of impacted molars).
For the subset of patients for whom rapid onset of analgesic effect is required and for whom the benefits outweigh the risk of discontinuation due to adverse events associated with higher initial doses, Pharmacy 50 mg to 100 mg can be administered as needed for pain relief every four to six hours, not to exceed 400 mg per day.
Previous US studies suggest a relatively low risk of seizures with Pharmacy, unless it is taken by people with epilepsy or taken with other drugs that reduce the seizure threshold.2-4
Since Pharmacy�s initial marketing, from March 1995 through June 2001, the FDA has received 912 domestic adverse-event reports classified under the coding terms \"drug dependence,\" \"drug withdrawal,\" or \"drug abuse\" in association with Pharmacy. (The use of these terms is not based on DSM-IV criteria but taken from the reports themselves and so will vary by reporting clinician.) The distribution by adverse-event term is as follows: dependence: N=426, withdrawal: N=407, abuse: N=241 (the sum exceeds 912 since a report may have included more than one adverse-event term).
Pharmacy should not be used in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed.
Nausea or vomiting may occur, especially after the first couple of doses. This effect may go away if you lie down for awhile. However, if nausea or vomiting continues, check with your medical doctor or dentist. Lying down for a while may also help relieve some other side effects, such as dizziness or lightheadedness, that may occur.
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Pharmacy is now widely prescribed in Australia, with 1.65 million prescriptions for oral Pharmacy issued under the Pharmaceutical Benefits Scheme in 2003.6 The Australian Adverse Drug Reactions Advisory Committee had received 83 reports of convulsions associated with Pharmacy to March 2004, although in only three cases was the association classified as �certain�.
Despite not being labeled habit-forming, there is a growing concern about Pharmacy addiction. Patients, especially those who have used the drug over a period of time, face great difficulty when they stop taking the drug. Cases have been reported wherein patients admit to physical and psychological dependence on the medicine. This withdrawal tendency seems to be a direct result of unlimited consumption or high-dose treatments. Patients have confirmed that withdrawals and pains may start if the medication is stopped suddenly.
Ultram (Pharmacy, Ultram ER, Ralivia, Ralivia ER, FlashDose) drug information, dosage, side effects, drug interactions, and warnings. Ultram, generic drug name Pharmacy hydrochloride, is a narcotic painkiller used for surgical, fibromyalgia, and arthritis pain. Other brand names of Pharmacy include: Ultram ER, Ralivia, Ralivia ER, and FlashDose.
Metabolism of Pharmacy and M1 is reduced in patients with advanced cirrhosis of the liver, resulting in both a larger area under the concentration time curve for Pharmacy and longer Pharmacy and M1 elimination half-lives (13 hrs. for Pharmacy and 19 hrs. for M1). In cirrhotic patients, adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
